Active Site

Iodothyronine deiodinase, active site (IPR008261)

Short name: Iodothyronine_deiodinase_AS


Iodothyronine deiodinase (EC: (DI) [PMID: 7592917] is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III is essential for the regulation of thyroid hormone inactivation during embryological development.

This signature found in the central part of the enzyme, which contains the active site selenocysteine.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004800 thyroxine 5'-deiodinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns