Pathways & interactions
Literature: FMN-dependent alpha-hydroxy acid dehydrogenase, active site (IPR008259)
References used in this entry
The following publications were referred to in the abstract:
The active site of spinach glycolate oxidase.
Lindqvist Y, Branden CI.
J. Biol. Chem. 264 3624-8 1989
PMID: 2644287 Related citations
L-lactate 2-monooxygenase from Mycobacterium smegmatis. Cloning, nucleotide sequence, and primary structure homology within an enzyme family.
Giegel DA, Williams CH Jr, Massey V.
J. Biol. Chem. 265 6626-32 1990
PMID: 2324094 Related citations
Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli.
Tsou AY, Ransom SC, Gerlt JA, Buechter DD, Babbitt PC, Kenyon GL.
Biochemistry 29 9856-62 1990
PMID: 2271624 Related citations
Amino acid sequence of long chain alpha-hydroxy acid oxidase from rat kidney, a member of the family of FMN-dependent alpha-hydroxy acid-oxidizing enzymes.
Diep Le KH, Lederer F.
J. Biol. Chem. 266 20877-81 1991
PMID: 1939137 Related citations
The following publications were not referred to in the abstract, but provide useful additional information:
Altered substrate specificity in flavocytochrome b2: structural insights into the mechanism of L-lactate dehydrogenation.
Mowat CG, Wehenkel A, Green AJ, Walkinshaw MD, Reid GA, Chapman SK.
Biochemistry 43 9519-26 2004
PMID: 15260495 Related citations
Crystal structure analysis of recombinant rat kidney long chain hydroxy acid oxidase.
Cunane LM, Barton JD, Chen ZW, Le KH, Amar D, Lederer F, Mathews FS.
Biochemistry 44 1521-31 2005
PMID: 15683236 Related citations
Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates.
Sukumar N, Dewanti A, Merli A, Rossi GL, Mitra B, Mathews FS.
Acta Crystallogr. D Biol. Crystallogr. 65 543-52 2009
PMID: 19465768 Related citations
Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.
Tsai CL, Gokulan K, Sobrado P, Sacchettini JC, Fitzpatrick PF.
Biochemistry 46 7844-51 2007
PMID: 17563122 Related citations
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design.
Murray MS, Holmes RP, Lowther WT.
Biochemistry 47 2439-49 2008
PMID: 18215067 Related citations