Active Site

FMN-dependent alpha-hydroxy acid dehydrogenase, active site (IPR008259)

Short name: FMN_hydac_DH_AS


A number of oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins have been shown [PMID: 2324094, PMID: 2271624, PMID: 1939137] to be structurally related. The first step in the reaction mechanism of these enzymes is the abstraction of the proton from the alpha-carbon of the substrate producing a carbanion which can subsequently attach to the N5 atom of FMN. A conserved histidine has been shown [PMID: 2644287] to be involved in the removal of the proton. The region around this active site residue is highly conserved and contains an arginine residue which is involved in substrate binding.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns