Vpu protein (IPR008187)

Short name: Vpu

Overlapping homologous superfamilies

Family relationships



The human immunodeficiency virus type 1 Vpu transmembrane protein is required for the induction of degradation human CD4 receptor degradation in the endoplasmic reticulum, and for the enhancement of virus particle release from the plasma membrane of infected cells. The cytoplasmic domain of Vpu directly interacts with the CD4 receptor, targeting it for proteasome degradation [PMID: 7853484]. The cytoplasmic domain encompasses the C-terminal half of the 81-residue protein, and is comprised of a few helical turns without an apparent hydrophobic core [PMID: 9182993]. The transmembrane domain of Vpu, found towards the N terminus, forms a cation-selective ion channel and is responsible for the enhancement of virus particle release [PMID: 14529626].

GO terms

Biological Process

GO:0032801 receptor catabolic process
GO:0019076 viral release from host cell

Molecular Function

GO:0005261 cation channel activity

Cellular Component

GO:0033644 host cell membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.