Phosphoribosyl-ATP pyrophosphohydrolase (IPR008179)

Short name: HisE

Overlapping homologous superfamilies


Family relationships


Phosphoribosyl-ATP pyrophosphatase, EC: catalyses the second step in the histidine biosynthetic pathway [PMID: 14342333]:

5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi

In E. coli, HisIE is encoded by the hisIE gene, which is formed by hisE gene fused to hisl [PMID: 11006846]. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity, respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins, all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate [PMID: 16359314, PMID: 15740738, PMID: 18560150, PMID: 3062174, PMID: 2163392, PMID: 9733547, PMID: 3018428, PMID: 1400209, PMID: 2664449, PMID: 9209067, PMID: 9778800, PMID: 7049842, PMID: 3005109].

GO terms

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0004636 phosphoribosyl-ATP diphosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.