Repeat

Collagen triple helix repeat (IPR008160)

Short name: Collagen

Description

Members of this family belong to the collagen superfamily [PMID: 8240831]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chains form a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post-translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy.

Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam