DNA photolyase class 2 (IPR008148)

Short name: DNA_photolyase_2

Overlapping homologous superfamilies

Family relationships



The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [PMID: 25910181, PMID: 26352435]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes [PMID: 7813451]. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.

Similar to the distantly related microbial class I photolyases, class 2 enzymes repair UV-induced cyclobutane pyrimidine dimer (CPD) lesions within duplex DNA using blue/near-UV light [PMID: 21892138]. There are a number of conserved sequence regions in all known class 2 DNA photolyases, especially in the C-terminal part. The structures of the class 2 DNA photolyase from archaea and rice have been solved [PMID: 21892138, PMID: 22170053].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003904 deoxyribodipyrimidine photo-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.