Family

Sequence-specific single-strand DNA-binding protein (IPR008116)

Short name: SSDP_DNA-bd

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The sequence-specific single-strand DNA-binding protein (SSDP) family is thought to be involved in transciption regulation. SSDP specifically binds single-stranded pyrimidine-rich mirror repeat elements commonly found in promoter regions, and is believed to regulate alpha-2(I) collagen [PMID: 9531483]. It has been identified as a target for unbalanced translocations and deletions in acute myelogenous leukemia cells, implying a role as a tumour suppressor gene. It is expressed in spleen, lymph node, peripheral blood, bone marrow, thymus and foetal liver. Family members have been identified in chicken, human, rat, mouse and Drosophila. The highest sequence identity is observed in the first 100 N-terminal residues, which contains a tryptophan-rich region in its centre. The C terminus is more viariable, with glycine/ proline-rich low complexity regions.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003697 single-stranded DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS