Cytoplasmic FMR1-interacting (IPR008081)

Short name: Cytoplasmic_FMR1-int

Overlapping homologous superfamilies


Family relationships


This entry includes cytoplasmic fragile X mental retardation protein interacting proteins from humans and their homologues, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis.

In humans, there are two members, CYFIP1 and CYFIP2. They both interact with FMRP (fragile X mental retardation protein), which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1 [PMID: 26824476, PMID: 11438699]. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E [PMID: 18805096]. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses [PMID: 27524794].

Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila [PMID: 15269173].

PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization [PMID: 15294869].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.