DNA replication licensing factor Mcm7 (IPR008050)
Short name: MCM7
The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm7 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [PMID: 17506634]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [PMID: 19896182, PMID: 19910535, PMID: 22841721]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [PMID: 22841721].
The components of the MCM2-7 complex are:
- DNA replication licensing factor MCM2, IPR008045
- DNA replication licensing factor MCM3, IPR008046
- DNA replication licensing factor MCM4, IPR008047
- DNA replication licensing factor MCM5, IPR008048
- DNA replication licensing factor MCM6, IPR008049
- DNA replication licensing factor MCM7, IPR008050
The human MCM7 gene has been localised to chromosome 7q21.3-q22.1. Increased expression of Mcm7 RNA and protein in MYCN-amplified neuroblastoma tumour and cell lines has been reported [PMID: 11861392]. Furthermore, The Mcm7 protein has been shown to form complexes with the retinoblastoma protein [PMID: 9566894]. These findings suggest Mcm7- directed DNA replication contributes to neoplastic transformation.