Mini-chromosome maintenance complex protein 4 (IPR008047)

Short name: MCM_4

Overlapping homologous superfamilies


Family relationships


The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm4 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [PMID: 17506634]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [PMID: 19896182, PMID: 19910535, PMID: 22841721]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [PMID: 22841721].

The components of the MCM2-7 complex are:

  • DNA replication licensing factor MCM2, IPR008045
  • DNA replication licensing factor MCM3, IPR008046
  • DNA replication licensing factor MCM4, IPR008047
  • DNA replication licensing factor MCM5, IPR008048
  • DNA replication licensing factor MCM6, IPR008049
  • DNA replication licensing factor MCM7, IPR008050

Mcm4 is thought to play a pivotal role in ensuring DNA replication occurs only once per cell cycle. Phosphorylation of Mcm4 dramatically reduces its affinity for chromatin - it has been proposed that this cell cycle-dependent phosphorylation is the mechanism that inactivates the MCM complex from late S phase through mitosis, thus preventing illegitimate DNA replication during that period of the cell cycle [PMID: 8901561].

GO terms

Biological Process

GO:0006270 DNA replication initiation

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity

Cellular Component

GO:0042555 MCM complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.