DNA replication licensing factor Mcm2 (IPR008045)

Short name: MCM2

Overlapping homologous superfamilies


Family relationships


The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm2 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [PMID: 17506634]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [PMID: 19896182, PMID: 19910535, PMID: 22841721]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [PMID: 22841721].

The components of the MCM2-7 complex are:

  • DNA replication licensing factor MCM2, IPR008045
  • DNA replication licensing factor MCM3, IPR008046
  • DNA replication licensing factor MCM4, IPR008047
  • DNA replication licensing factor MCM5, IPR008048
  • DNA replication licensing factor MCM6, IPR008049
  • DNA replication licensing factor MCM7, IPR008050

In addition to its role in initiation of DNA replication, Mcm2 is able to inhibit the Mcm4,6,7 helicase. Studies on murine Mcm2 indicate that its C terminus is required for interaction with MCM4, as well as for inhibition of the DNA helicase activity of the Mcm4,6,7 complex. The N-terminal region, which contains an H3-binding domain and a region required for nuclear localisation, is required for the phosphorylation by CDC7 kinase.

GO terms

Biological Process

GO:0006270 DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding

Cellular Component

GO:0042555 MCM complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.