Family

Glycogen synthase kinase-3 binding protein (IPR008014)

Short name: GSK3-bd

Family relationships

None.

Description

Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3 [PMID: 11738041].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam