Macrophage colony stimulating factor-1 (IPR008001)

Short name: MCSF-1

Overlapping homologous superfamilies


Family relationships



Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility [PMID: 11897698] and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption [PMID: 12379742].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005125 cytokine activity
GO:0008083 growth factor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.