Family

Scorpion short chain toxin, chloride channel inhibitor (IPR007958)

Short name: Scorpion_toxinS_Cl_inh

Family relationships

None.

Description

Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulphide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8 [PMID: 7819188, PMID: 9210487, PMID: 10048185].

The global fold of the scorpion short toxin chloride channel inhibitor subfamily is an alpha-helix packed on a two-stranded beta-sheet. The structure also contains a short fragment in an extended form. The two antiparalllel beta-strands are connected by a type I beta-turn. The four disulphide bridges help to maintain a very compact structure by heavily attaching the N-terminal and C-terminal ends to the alpha-helix [PMID: 7819188, PMID: 9210487, PMID: 10048185].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
  • PS51200 (SHORT_SCORPION_CHLORIDE)
Pfam