Domain

Malonyl-CoA decarboxylase, C-terminal (IPR007956)

Short name: Malonyl_CoA_deC_C

Domain relationships

None.

Description

Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK) [PMID: 12065578].

This entry represents the C-terminal catalytic domain of Malonyl-CoA decarboxylase [PMID: 23791943].

GO terms

Biological Process

GO:0006633 fatty acid biosynthetic process

Molecular Function

GO:0050080 malonyl-CoA decarboxylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam