Keratin-associated protein, PMG type (IPR007951)

Short name: KRTAP_PMG

Overlapping homologous superfamilies


Family relationships



This entry represents the keratin-associated proteins, PMG type [PMID: 10446281]. The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulphide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulphur (HS) and ultra-high-sulphur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.

Other groups of keratin-associated proteins include IPR020184 and IPR021743.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.