Neuroendocrine 7B2 precursor (IPR007945)

Short name: Secretogranin_V

Overlapping homologous superfamilies


Family relationships



Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PMID: 10701998]. Protein 7B2 (secretogranin V) functions as a molecular chaperone for PC2, preventing its premature activation in the regulated secretory pathway [PMID: 7913882]. 7B2 represents a potent inhibitor of PC2, and it is also required for the activation of PC2, which is synthesised as a zymogen. Protein 7B2 has an N-terminal activation domain and a C-terminal (CT) inhibitory domain (MEROPS inhibitor family I21), separated by a furin cleavage site [PMID: 10506829]. 7B2 is synthesised as a precursor protein that is cleaved into the N-terminal fragment and the C-terminal peptide [PMID: 11439082].

GO terms

Biological Process

GO:0007218 neuropeptide signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030141 secretory granule

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.