Family

Mitochondrial distribution/morphology family 35/apoptosis (IPR007918)

Short name: MDM35_apoptosis

Family relationships

None.

Description

This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) O60200 is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM) [PMID: 11907266]; wherease in Homo sapiens (Human), p53CSV, O43715 is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including low-levels of DNA damage. It is suggested that p53CSV modulates the apoptotic pathway through interaction with HSP70 and Apaf-1 thereby inhibiting activation of procaspase-3 and procaspase-9 [PMID: 15735003].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam