Family

Glycosylation-dependent cell adhesion molecule 1 (IPR007906)

Short name: GLYCAM-1

Family relationships

None.

Description

This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has been shown to be a critical structural requirement to be recognised by L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus and rat cochlea [PMID: 12057858].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom