Transcription initiation factor TFIID component TAF4 (IPR007900)

Short name: TAF4

Overlapping homologous superfamilies


Domain relationships



Accurate transcription initiation at protein-coding genes by RNA polymerase II requires the assembly of a multiprotein complex around the mRNA start site. Transcription factor TFIID is one of the general factors involved in this process. Yeast TFIID comprises the TATA binding protein and 14 TBP-associated factors (TAFIIs), nine of which contain histone-fold domains. The C-terminal region of the TFIID-specific yeast TAF4 (yTAF4) containing the HFD shares strong sequence similarity with Drosophila (d)TAF4 and human TAF4. A structure/function analysis of yTAF4 demonstrates that the HFD, a short conserved C-terminal domain (CCTD), and the region separating them are all required for yTAF4 function. This region of similarity is found in Transcription initiation factor TFIID component TAF4 [PMID: 12237303].

TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes [PMID: 19635797, PMID: 12237304].

GO terms

Biological Process

GO:0006352 DNA-templated transcription, initiation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005669 transcription factor TFIID complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.