CHAD domain (IPR007899)

Short name: CHAD_dom

Overlapping homologous superfamilies

Domain relationships



The CHAD (conserved histidine alpha-helical domain) is an uncharacterised domain, with a characteristic pattern of conserved histidines and other charged residues. It is predicted to adopt an alpha-helical fold. The sequence conservation pattern suggests that this domain is likely to contain two repeat units, with at least 4 helices each, at its core. The conserved charged residues could form a strongly polar surface that could participate, either in metal chelation, or act as phosphoacceptors [PMID: 12456267].

Some proteins known to contain a CHAD domain are listed below:

  • Escherichia coli uncharacterised protein YgiF.
  • Mycobacterium tuberculosis uncharacterised protein Rv2226/MT2285.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles