NTF2-like N-terminal transpeptidase (IPR007887)

Short name: MecA_N

Overlapping homologous superfamilies


Domain relationships



The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. Methicillin resistance in MRSA strains is due to the acquisition of the mecA gene via horizontal transfer from an unidentified species which encodes penicillin-binding protein 2a (PBP2a).

The structure of the N-terminal domain from MecA is known [PMID: 12389036] Q53707 and is found to be similar to that found in NTF2 IPR002075. The length of the PBP2A N-terminal domain (which positions the transpeptidase active site more than 100A from the expected C terminus of the transmembrane anchor) suggests a possible structural role and potentially gives the transpeptidase domain substantial reach from the cell membrane. This domain seems unlikely to have an enzymatic function.

GO terms

Biological Process

GO:0046677 response to antibiotic

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.