Family

Microtubule-associated protein 6 (IPR007882)

Short name: MAP6

Family relationships

  • MAP6/FAM154 (IPR024963)
    • Microtubule-associated protein 6 (IPR007882)

Description

Microtubule-associated protein 6 (MAP6) is a calmodulin binding protein that is involved in microtubule stabilisation [PMID: 16806091].

Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. MAP6 is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity [PMID: 12231625]. MAP6 interacts with TMEM106B, and this interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport [PMID: 24357581]. TMEM106B is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology.

GO terms

Biological Process

GO:0048813 dendrite morphogenesis
GO:0032418 lysosome localization
GO:0000226 microtubule cytoskeleton organization

Molecular Function

GO:0005516 calmodulin binding
GO:0008017 microtubule binding

Cellular Component

GO:0005874 microtubule

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER