Family

Sprouty (IPR007875)

Short name: Sprouty

Overlapping homologous superfamilies

None.

Family relationships

Description

Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [PMID: 15683364, PMID: 12391162]. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain [PMID: 15683364, PMID: 12391162, PMID: 10887178, PMID: 11493923]. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential [PMID: 12402043, PMID: 12391162]. It also mediates homodimer formation of these proteins [PMID: 15683364, PMID: 12402043].

The SPR domain can occur in association with the WH1 domain (see IPR000697) (located in the N-terminal part of the proteins) in the Spred proteins.

GO terms

Biological Process

GO:0007275 multicellular organism development
GO:0009966 regulation of signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam