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Overview
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Pathways & interactions
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Structures
Sprouty (IPR007875)
Short name: Sprouty
Overlapping homologous superfamilies
None.
Family relationships
- Sprouty (IPR007875)
- Protein sprouty homologue 1 (IPR030783)
- Protein sprouty homologue 2 (IPR030780)
- Protein sprouty homologue 3 (IPR030786)
- Protein sprouty homologue 4 (IPR030790)
Description
Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [PMID: 15683364, PMID: 12391162]. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain [PMID: 15683364, PMID: 12391162, PMID: 10887178, PMID: 11493923]. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential [PMID: 12402043, PMID: 12391162]. It also mediates homodimer formation of these proteins [PMID: 15683364, PMID: 12402043].
The SPR domain can occur in association with the WH1 domain (see IPR000697) (located in the N-terminal part of the proteins) in the Spred proteins.
GO terms
Biological Process
GO:0007275 multicellular organism development
GO:0009966 regulation of signal transduction
Molecular Function
No terms assigned in this category.
Cellular Component
GO:0016020 membrane