Homing endonuclease PI-Sce (IPR007869)

Short name: Homing_endonuc_PI-Sce

Overlapping homologous superfamilies


Domain relationships



Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [PMID: 12219083] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a second domain containing the protein-splicing active site.

GO terms

Biological Process

GO:0030908 protein splicing

Molecular Function

GO:0003677 DNA binding
GO:0004519 endonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.