Protein arginine N-methyltransferase PRMT5 (IPR007857)

Short name: Arg_MeTrfase_PRMT5

Overlapping homologous superfamilies


Family relationships


This entry represents a group of arginine N-methyltransferases, including Skb1 from S. pombe [PMID: 11278267], Hsl7 from S. cerevisiae [PMID: 10903903] and their homologues PRMT5 from animals [PMID: 10531356, PMID: 11152681, PMID: 17709427] and plants [PMID: 17363895]. Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe [PMID: 11278267]. Plant PMRT15 is involved in the post-transcriptional regulation of the circadian clock [PMID: 20962777]. Human PRMT5 is a component of multiple protein complexes and contributes to essential cellular processes, such as RNA transport and splicing, cell cycle regulation, tumour growth, and chromatin remodelling, leading to either gene silencing or activation [PMID: 22269951].

GO terms

Biological Process

GO:0035246 peptidyl-arginine N-methylation
GO:0006479 protein methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.