Family

RNA-dependent RNA polymerase, eukaryotic-type (IPR007855)

Short name: RNA-dep_RNA_pol_euk-typ

Family relationships

None.

Description

This entry represents various eukaryotic RNA-dependent RNA polymerases (RDRP; EC:2.7.7.48), such as RCRP-1, RDRP-2 and RDRP-6. These enzymes are involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing [PMID: 12553882]; they are also required for transcriptional gene silencing. Double-stranded RNA has been shown to induce gene silencing in diverse eukaryotes and by a variety of pathways [PMID: 16691418]. These enzymes also play a role in the RNA interference (RNAi) pathway, which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. RDRP enzymes are highly conserved in most eukaryotes, but are missing in archaea and bacteria. The core catalytic domain of RDRP enzymes is structurally similar to the beta' subunit of DNA-dependent RNA polymerases (DDRP), however the other domains of DDRP show no similarity to those of RDRP.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003968 RNA-directed RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER