Cdc73/Parafibromin (IPR007852)

Short name: Cdc73/Parafibromin

Overlapping homologous superfamilies

Family relationships



This entry includes Cdc73 from budding yeasts and its animal homologue, parafibromin. They are part of the Paf1 complex involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [PMID: 20178742].

In budding yeasts, Paf1 is an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. It is required for full expression of a subset of yeast genes, particularly those responsive to signals from the Pkc1/MAP kinase cascade. The complex appears to play an essential role in RNA elongation [PMID: 12242279].

Human parafibromin is a tumour suppressor that may facilitate association of 3' mRNA processing factors with actively-transcribed chromatin. It is a component of the human Paf1 complex (Paf1C), which consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications [PMID: 20178742].

The Arabidopsis Cdc73 (also known as PLANT HOMOLOGOUS TO PARAFIBROMIN ,PHP) assists in regulating expression of genes within H3K27ME3-enriched chromatin [PMID: 20363855] and participates in the modification of FLOWERING LOCUS C (FLC) chromatin [PMID: 20463090].

GO terms

Biological Process

GO:0016570 histone modification
GO:0006368 transcription elongation from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016593 Cdc73/Paf1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.