Ribosomal RNA processing protein 8 (IPR007823)

Short name: RRP8

Overlapping homologous superfamilies


Family relationships



Ribosomal RNA processing protein 8 (Rrp8) is a nucleolar Rossman-fold like methyltransferase. In yeast, it is involved in pre-rRNA cleavage at site A2 [PMID: 10864042] and is responsible for a base methylation of the 25S rRNA [PMID: 23180764]. In humans it is also known as nucleomethylin (NML), and it is important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which regulates rRNA transcription in response to glucose deprivation [PMID: 23897426]. NML represses rDNA transcription by promoting H3K9 methylation and establishing heterochromatin across the rDNA [PMID: 18485871].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

GO:0005730 nucleolus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.