Lanthionine synthetase C-like (IPR007822)

Short name: LANC-like

Overlapping homologous superfamilies


Family relationships


The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [PMID: 11474189, PMID: 10944443, PMID: 12566319]; subtilin biosynthesis protein SpaC from Bacillus subtilis [PMID: 1735728, PMID: 1539969]; epidermin biosynthesis protein EpiC from Staphylococcus epidermidis [PMID: 1740156]; nisin biosynthesis protein NisC from Lactococcus lactis [PMID: 8161176, PMID: 7689965, PMID: 1482192]; GCR2 from Arabidopsis thaliana [PMID: 17347412]; and many others.

The 3D structure of the lantibiotic cyclase from L. lactis has been determined by X-ray crystallography to 2.5A resolution [PMID: 16527981]. The globular structure is characterised by an all-alpha fold, in which an outer ring of helices envelops an inner toroid composed of 7 shorter, hydrophobic helices. This 7-fold hyrophobic periodicity has led several authors to claim various members of the family, including eukaryotic LanC-1 and GCR2, to be novel G protein-coupled receptors [PMID: 17347412, PMID: 9512664]; some of these claims have since been corrected [PMID: 10944443, PMID: 18086512, PMID: 17894782].

The C terminus of the lantibiotic biosynthesis protein LanM is homologous to LanC [PMID: 19393544, PMID: 23071302].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.