Type II secretion system protein L (IPR007812)

Short name: T2SS_protein-L

Overlapping homologous superfamilies


Family relationships



This family consists of general secretion pathway protein L sequences from several Gram-negative bacteria. The general secretion pathway (also called type II secretion) of Gram-negative bacteria is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. GspL is predicted to contain a large cytoplasmic domain and has been shown to interact with the autophosphorylating cytoplasmic membrane protein GspE. It is thought that the tri-molecular complex of GspL, GspE and GspM might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation [PMID: 10322014].

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

GO:0008565 protein transporter activity

Cellular Component

GO:0009276 Gram-negative-bacterium-type cell wall
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.