Helicase domain (IPR007807)

Short name: Helicase_dom

Overlapping homologous superfamilies


Domain relationships



This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [PMID: 19322199]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [PMID: 15538360].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.