Family

Transcription factor AF4/FMR2 (IPR007797)

Short name: TF_AF4/FMR2

Family relationships

None.

Description

This family consists of family member 1 (proto-oncogene AF4), family member 2 or FMR2 (Fragile X E mental retardation syndrome), family member 3 or LAF4 (lymphoid nuclear protein related to AF4) and family member 4 (protein lilliputian). Lilliputian is a Drosophila AF4 protein homologue which contains an AT-hook domain. It represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [PMID: 11171404].

These proteins have been linked to Homo sapiens diseases such as acute lymphoblastic leukemia and mental retardation [PMID: 11171403].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER