Anamorsin (IPR007785)

Short name: Anamorsin

Family relationships



Anamorsin (also named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1), is the human homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis [PMID: 20802492, PMID: 21700214]. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [PMID: 18625724]. Anamorsin is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [PMID: 18299278]. In addition, it mediates the anti-apoptotic effects of various cytokines [PMID: 14970183].

GO terms

Biological Process

GO:0016226 iron-sulfur cluster assembly

Molecular Function

GO:0051536 iron-sulfur cluster binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.