-
Overview
Family
Alpha-N-acetylglucosaminidase (IPR007781)
Short name: NAGLU
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate [PMID: 10588735]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [PMID: 12049639].
Contributing signatures
Signatures from InterPro member databases are used to construct an entry.
PANTHER
- PTHR12872 (PTHR12872)