Family

Leukocyte-specific transcript 1, LST-1 (IPR007775)

Short name: Leukocyte-sp_tscrpt_1_LST1

Family relationships

None.

Description

B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia [PMID: 11478849].

A possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation [PMID: 10706707, PMID: 11478849].

GO terms

Biological Process

GO:0000902 cell morphogenesis
GO:0006955 immune response

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF
Pfam