Suppressor of fused (IPR007768)

Short name: Suppressor_of_fused

Overlapping homologous superfamilies

Family relationships


Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [PMID: 12150819], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway [PMID: 12068298]. Homologues of Sufu have been found in bacteria, though their function is not currently known.

This entry represents the eukaryotic suppressor of fused proteins and their bacterial homologues.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.