Family

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (IPR007763)

Short name: NDUFA12

Family relationships

None.

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This entry includes the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12) and the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (NDUFAF2). NDUFA12 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) [PMID: 14741580]. NDUFA12 is believed not to be involved in catalysis [PMID: 12611891]. NDUFAF2 is a paralogue of the structural subunit NDUFA12 and functions as an assembly factor [PMID: 23648483].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron carrier activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER