Family

N-acetylglucosaminyltransferase II (IPR007754)

Short name: GlcNAc_II

Family relationships

None.

Description

N-acetylglucosaminyltransferase II (EC:2.4.1.143) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [PMID: 7797505]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors [PMID: 11596651].

Synonym(s): UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II, GnT II/MGAT2.

GO terms

Biological Process

GO:0009312 oligosaccharide biosynthetic process

Molecular Function

GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

Cellular Component

GO:0005795 Golgi stack
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER