Mga helix-turn-helix domain (IPR007737)

Short name: Mga_HTH

Overlapping homologous superfamilies


Domain relationships



M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [PMID: 11952907]. This domain is found in the centre of the Mga proteins. This domain is also found in a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins [PMID: 11988525]. This is presumably a DNA-binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.