Heparan sulphate 2-O-sulfotransferase (IPR007734)

Short name: Heparan_SO4_2-O-STrfase

Overlapping homologous superfamilies


Family relationships

  • Sulfotransferase (IPR005331)
    • Heparan sulphate 2-O-sulfotransferase (IPR007734)


Heparan sulphate (HS) is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix, where it acts as a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS-O-sulphotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulphate to the C2-position of selected hexuronic acid residues within the nascent HS chain. Mice that lack HS2ST undergo developmental failure after midgestation, the most dramatic effect being the complete failure of kidney development [PMID: 11956326]. This family is related to IPR005331.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008146 sulfotransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.