N-acetylglucosaminyl transferase component (IPR007720)

Short name: GlcNAc_Gpi1

Overlapping homologous superfamilies


Family relationships



Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both Saccharomyces cerevisiae (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively [PMID: 11849707].

GO terms

Biological Process

GO:0006506 GPI anchor biosynthetic process

Molecular Function

GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.