Nuclear pore localisation protein NPL4, C-terminal (IPR007717)

Short name: NPL4_C

Overlapping homologous superfamilies


Domain relationships



The HRD4 gene is identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation following ubiquitination of target proteins but preceding their recognition by the 26S proteasome [PMID: 11739805]. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing [PMID: 11574150].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.