Nucleoside 2-deoxyribosyltransferase (IPR007710)

Short name: Nucleoside_deoxyribTrfase

Family relationships


Nucleoside 2-deoxyribosyltransferase (EC: catalyses the cleavage of the glycosidic bonds of 2-deoxyribonucleosides. Nucleoside 2-deoxyribosyltransferases can be divided into two groups based on their substrate specificity: class I enzymes are specific for the transfer of deoxyribose between two purines, while class II enzymes will transfer the deoxyribose between either purines or pyrimidines. The structure of the class I [PMID: 14992575] and class II [PMID: 8805514] enzymes are very similar. In class I enzymes, the purine base shields the active site from solvent, which the smaller pyrimidine base cannot do, while in class II enzymes the active site is shielded by a loop (residues 48-62). Both classes of enzymes are found in various Lactobacillus species and participate in nucleoside recycling in these microorganisms. This entry represents both classes of enzymes.

GO terms

Biological Process

GO:0009159 deoxyribonucleoside monophosphate catabolic process

Molecular Function

GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
GO:0050144 nucleoside deoxyribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.