Domain

Transforming acidic coiled-coil-containing protein, C-terminal (IPR007707)

Short name: TACC_C

Domain relationships

None.

Description

This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) [PMID: 11121038]. TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis [PMID: 25262927]. Maskin is also found to bind CPEB and elF-4E [PMID: 10635326]. Interestingly, the functional homologue (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organisation of bipolar spindles [PMID: 14742702].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam