SGS domain (IPR007699)

Short name: SGS_dom

Overlapping homologous superfamilies


Domain relationships



The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic Sgt1 proteins [PMID: 11847307]. It was latter also found in calcyclin-binding proteins [PMID: 12746458]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [PMID: 12746458].

Sgt1 is a highly conserved eukaryotic protein that is required for both SCF (Skp1p/Cdc53p-Cullin-F-box)-mediated ubiquitination and kinetochore function in yeast and also plays a role in the cAMP pathway. Calcyclin (S100A6) is a member of the S100A family of calcium binding proteins and appears to play a role in cell proliferation [PMID: 12577318].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles