Domain

DNA helicase, DnaB-like, N-terminal (IPR007693)

Short name: DNA_helicase_DnaB-like_N

Overlapping homologous superfamilies

Domain relationships

None.

Description

The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity. This domain has a multi-helical structure that forms an orthogonal bundle [PMID: 10404598].

GO terms

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0005524 ATP binding
GO:0003678 DNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam