RelA/SpoT (IPR007685)

Short name: RelA_SpoT

Domain relationships



The functions of Escherichia coli RelA and SpoT differ somewhat. RelA (EC: produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC: degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homologue to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation.

(p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species.

GO terms

Biological Process

GO:0015969 guanosine tetraphosphate metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.