Domain

Arabinofuranosyltransferase, N-terminal (IPR007680)

Short name: Arabino_trans_N

Domain relationships

None.

Description

Arabinosyltransferases EmbA, EmbB and EmbC are known to be involved in arabinogalactan (AG) and lipoarabinomannan (LAM) biosynthesis in mycobacteria. Synthesis of LAM, but not AG, ceases after inactivation of EmbC, while the arabinan of AG is affected by EmbA or EmbB disruption [PMID: 14507364]. The arabinans of the mycobacterial cell wall are key structural and immunological polymers. These enzymes could have important clinical applications as they are believed to be the target of the antimycobacterial drug Ethambutol [PMID: 8876238].

This entry represents the N-terminal domain found in arabinosyltransferase EmbA, EmbB and EmbC.

GO terms

Biological Process

GO:0071766 Actinobacterium-type cell wall biogenesis

Molecular Function

GO:0052636 arabinosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam